Membrane Adsorber

for Ion Exchange Chromatography with i3 Digital Membrane Chromatography

The i3 Digital Membrane Chromatography Adsorber is designed for the efficient and gentle purification of biomolecules using the i3 Digital Membrane Chromatograpy (DMC) method.

Ideal for rapid capture and release of highly concentrated biomolecules, monoclonal antibodies and Fc-containing molecules
Enables work in small-scale applications such as research, screening and process development

i3 DMC CEX i3 DMC AEX

Its charged surface enhances the binding and separation process, providing rapid purification without compromising the integrity of your samples via DMC. Featuring an integrated ultra-thin gold membrane and contact pins on the housing, this advanced design allows for precise application of an electric field via the i3 DMC_ontrol Smart Control Unit. This ensures optimal control over the elution process, enhancing both performance and consistency.

The Membrane Adsorber is equipped with Luer-Lock connectors for seamless integration with liquid chromatography (LC) systems, making it easy to incorporate into your existing workflows for maximum convenience and flexibility.

i3 DMC CEX

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The i3 DMC^CEX is intended for the purification of positively charged biomolecules
using electric potential for elution. It enables a rapid purification of highly concentrated eluates for drug discovery applications and in the productions of biomolecules for research and development.

Rapid and gentle purification on negatively charged biomolecules
Ideal for small-scale application, e.g. research and process development
Highly concentrated eluates without aggregation through multiple elution cycles
No buffer exchange

Membrane	Polyamide (PA)
Pore size	0.2 µm
Effective filtration area	22.0 mm \| 0.89″
Membrane thickness	0.11 mm \| 0.004″
Bed volume	0.04 mL
Dynamic binding capacity per unit	1.1 mg Lysozyme (Determined in 0.24 mM PBS, pH 7.4)
Recommended operating flow rate	2.0 mL/min
Maximum operating pressure	3 bar \| 43.5 psi
Recommended elution voltage	+ 2 V
Temperature stability	4°C-RT @ 39.2°F-RT
Connectors	Luer-Lock
Autoclavability	non autoclavable
Dimensions	H: 34.0 mm \| 1.3″ Ø: 29.7 mm \| 1.2″

i3 DMC AEX

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The i3 DMC^AEX is intended for the purification of negatively charged biomolecules using electrical potential for elution. Digital Membrane Chromatography (DMC) enables a rapid purification of highly concentrated eluates, ideal for drug discovery applications and the production of biomolecules for research and development purposes. The Anion Exchange Membrane Adsorber is equipped with four pins enabling the electric potential to be precisely directed onto the membrane. It can be easily integrated into a liquid chromatography system using Luer-Lock connection.

Rapid and gentle purification of negatively charged biomolecules
Ideal for small-scale application, e.g. research and process development
Highly concentrated eluates without aggregation
No buffer exchannge
Easy connection to penstaltic pump or chromatography systems

Membrane	Polyamide (PA)
Pore size	0.2 µm
Effective filtration area	Ø 22.0 mm \| Ø 0.89″
Membrane thickness	0.11 mm \| 0.004″
Bed volume	0.04 mL
Dynamic binding capacity per unit	0.6 mg BSA (Determined in 0.24 mM PBS, pH 7.4)
Recommended operating flow rate	2.0 mL/min
Maximum operating pressure	3 bar \| 43.5 psi
Recommended elution voltage	– 2 V
Temperature stability	4°C-RT @ 39.2°F-RT
Connectors	Luer-Lock
Autoclavability	non autoclavable
Dimensions	H: 34.0 mm \| 1.3″ Ø: 29.7 mm \| 1.2″