We are excited to announce the launch of the new i3 DMC PrA 1.0 mL, a ready-to-use Protein A membrane adsorber featuring mild, electrically driven elution. Developed for the purification of IgG, monoclonal antibodies and other Fc-containing molecules, its larger bed volume provides more purified antibody material and opens up new possibilities for extended analytical and early discovery workflows. The underlying i3 DMC technology remains unchanged: Established Protein A affinity capture is combined with the same innovative elution principle. Instead of a conventional low-pH buffer, the i3 DMC Control applies an electrical potential directly to the membrane to release the bound target molecules. This mild approach is particularly relevant for sensitive and pH-labile antibodies.
More purified material for a broader range of applications
As antibody candidates progress through early discovery, the amount of purified material required often increases. While smaller quantities may be sufficient for initial screening, broader analytical programs and early in vivo pharmacology studies typically require more material. With a membrane volume of 1.0 mL and a dynamic binding capacity of up to 30 mg polyclonal IgG per unit, the new format supports this transition. The resulting purified samples can support downstream workflows including mass spectrometry, ELISA, biolayer interferometry (BLI), SPA, and early in vivo studies.
An important milestone for the DMC platform
The increase in membrane volume from 0.1 mL to 1.0 mL represents more than the addition of a new product size. This tenfold scale-up demonstrates that the core principle of electrically driven DMC elution can be successfully transferred to a larger membrane format. It confirms the scalability of the technology and marks an important step in the continued development of the DMC platform. The larger format also broadens the range of purification workflows that can be addressed and provides a foundation for future applications requiring higher sample volumes.
More information about the i3 DMC PrA 1.0 mL is available on our product page.