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DMC is short for Digital Membrane Chromatography.
DMC elution is a novel approach that uses electrical potential for elution. This method enables rapid and gentle elution of biomolecules from chromatography membranes, avoiding the need of elution buffer adjustments. DMC makes the purification process more efficient, maintaining a stable environment that significantly reduces aggregation risks and enhances recovery yields.
To perform DMC elution with i3 DMC Membrane Absorber, you need i3 DMControl with uniquely designed connecting cables. And a chromatography system or a peristaltic pump. The Membrane Adsorber is equipped with Luer lock connectors. These connectors can be seamlessly integrated with a chromatography system using appropriate fittings.
Nähere Informationen zur Ausstattung und Installation des i3 DMC Membranadsorbers und des i3 DMControl can be found at www.i3membrane.com/biotech
Commonly used buffer systems in neutral pH (e.g. PBS buffer pH 7.4) can be used with i3 DMC Membrane Adsorber. It is crucial that the DMC elution is performed using the recommended buffer system. Conductivity can be used as a guideline. We recommend not exceeding the specified conductivity levels. AEX: 0.5 mS/cm CEX : 0.6 mS/cm PrA : 0.6 mS/cm
More detailed information about recommended buffer systems during i3 standard methods can be found in data sheets and manuals of appropriate i3 Membrane Adsorbers at www.i3membrane.com/biotech